Ion channels and myogenic activity in retinal arterioles.

Retinal pressure autoregulation is an important mechanism that protects the retina by stabilizing retinal blood flow during changes in arterial or intraocular pressure. Similar to other vascular beds, retinal pressure autoregulation is thought to be mediated largely through the myogenic response of small arteries and arterioles which constrict when transmural pressure increases or dilate when it decreases.

Over recent years, we and others have investigated the signaling pathways underlying the myogenic response in retinal arterioles, with particular emphasis on the involvement of different ion channels expressed in the smooth muscle layer of these vessels.

Here, we review and extend previous work on the expression and spatial distribution of the plasma membrane and sarcoplasmic reticulum ion channels present in retinal vascular smooth muscle cells (VSMCs) and discuss their contribution to pressure-induced myogenic tone in retinal arterioles.

This includes new data demonstrating that several key players and modulators of the myogenic response show distinctively heterogeneous expression along the length of the retinal arteriolar network, suggesting differences in myogenic signaling between larger and smaller pre-capillary arterioles.

Neuregulin/Heregulin-1? (NRG-1?/HRG-1?), human recombinant protein

P1054-1 1 mg
EUR 3947.00
Description: Neuregulin (NRG) is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells and plays an important role in heart structure and function through inducing cardiomyocyte differentiation

Angiotensin 1/2 (1-7) amide

A1054-1 1 mg
EUR 96.00
Description: Angiotensin I/II (1-7) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-amide) is a peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory collapse.

Angiotensin 1/2 (1-8) amide

A1055-1 1 mg
EUR 96.00
Description: The physiologically active peptide angiotensin-2 (angiotensin 1- 8) is yielded from angiotensin-1, a substrate of ACE (angiotensin converting enzyme), by removing a dipeptide.

Endothelin-1 (1-15), amide, human

A1111-1 1 mg
EUR 722.00
Description: Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium and have a key role in vascular homeostasis.

Haptoglobin, (Phenotype 1-1) Human Plasma

7536-1
EUR 321.00

UK 1

C5006-1 1 mg
EUR 363.00
Description: UK 1, an unusual bis-benzoxazole metabolite isolated from Streptomyces sp. 517-02, is an inhibitor of topoisomerase II (Topo II) and hepatitis C viral replication.

KP372-1

C5053-1 1 mg
EUR 132.00
Description: IC50: 30-60 nM for thyroid cancer cells KP372-1 is a specific Akt inhibitor. The phosphatidylinositol 3' kinase (PI3K)/phosphatase, which is a key regulator of cell proliferation and survival, is mutated or activated in various cancers.

4EGI-1

B2901-1
EUR 142.00

ADWX 1

B5722-.1 100 ug
EUR 583.00
Description: ADWX 1 is a potent and selective inhibitor of KV1.3 channel with IC50 values of 1.89 pM and 0.65 nM for Kv1.3 and Kv1.1, respectively [1].

Purotoxin 1

B5771-.1 100 µg
EUR 380.00

Shz 1

B5772-1 1 mg
EUR 118.00

Psalmotoxin 1

B5796-.1 100 ug
EUR 447.00
Description: IC50: 0.9 nMPsalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.Several ASIC subunits described: ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3 with different kinetics, tissue distribution, and external pH sensitivities.

TAPI-1

B4686-1 1 mg
EUR 268.00
Description: TAPI-1 is an inhibitor of tumour necrosis factor with IC50 value of 8.09 ?M [1].TAPI-1 is an inhibitor of TACE/ADAM17 which catalyzes the cleavage of full-length APP to the soluble N-terminal fragment (sAPP?).

C14TKL-1

B5240-1 1 mg
EUR 399.00

?1-MSH

B5427-1 1 mg
EUR 268.00

MMK 1

B5446-1 1 mg
EUR 268.00

CRSP-1

B5452-.1 100 ug
EUR 415.00

Flutax 1

B6986-1 1 mg
EUR 399.00

IDE 1

B7566-1 1 mg
EUR 118.00

Rbin-1

B7823-1 1 mg
EUR 154.00
Description: Rbin-1 is an eukaryotic ribosome assembly inhibitor.All cellular proteins are synthesized by ribosomes, whose biogenesis is a complex multi-step process quickly completed in eukaryotes.

IQ-1

1663-1
EUR 204.00

Shz-1

1915-1
EUR 137.00

1-Azakenpaullone

1944-1
EUR 289.00

StemRegenin 1

1967-1
EUR 147.00

SANT-1

1978-1
EUR 126.00

IDE-1

2193-1
EUR 147.00

PFI-1

2203-1
EUR 115.00

TAPI-1

2068-1
EUR 398.00

CMPD-1

B2991-1 1mg
EUR 125.00

IL-1-beta Interleukin-1 betaHuman Recombinant Protein

PROTP01584-1 Regular: 10ug
EUR 317.00
Description: Interleukin-1 beta Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton.;The IL-1b is purified by proprietary chromatographic techniques.

MMP-1 Matrix Metalloproteinase-1 Human Recombinant Protein

PROTP03956-1 Regular: 20ug
EUR 317.00
Description: MMP 1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 393 amino acids (100-469a.a) and having a molecular mass of 45kDa. MMP 1 is fused to a 23 amino acid His-tag at N-terminus.

Anti-HO-1 Monoclonal Antibody (HO-1-2)

M00253-1 1mg
EUR 397.00
Description: Mouse Monoclonal HO-1 Antibody (HO-1-2). Validated in Flow Cytometry, IHC, WB and tested in Human, Mouse, Rat.

RN-1 (hydrochloride)

C4247-1 1 mg
EUR 112.00
Description: RN-1 (hydrochloride) is a brain-penetrant, potent and irreversible LSD1 inhibitor with IC50 values of 10-70 nM [1]. Lysine-specific demethylase 1 (LSD1) is a flavin-dependent monoamine oxidase that demethylate mono- and di-methylated lysines, specifically histone 3, lysines 4 and 9.

Teicoplanin A3-1

C4943-1 1 mg
EUR 326.00
Description: Teicoplanin A3-1, also known as Antibiotic L 17054, is a glycopeptide antibiotic derived from Actinoplanes teichomyceticus and produces a potent broad spectrum antibiotic activity against gram-positive bacteria.

TASIN-1 hydrochloride

B2088-1
EUR 142.00

1-NM-PP1

B2346-1
EUR 142.00

PACAP 1-38

B6625-1 1 mg
EUR 347.00

Sphingosine-1-phosphate

B6707-1 1 mg
EUR 181.00
Description: Sphingosine-1-phosphate is an endogenous second messenger that involved in cell proliferation and survival and is a ligand for S1PR1 [1] [2].

HPGDS inhibitor 1

B1046-1 1 mg
EUR 181.00
Description: HPGDS inhibitor 1 is an oral potent and selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS) with IC50 value of 0.7nM [1].Prostaglandin D2 (PGD2) is a mediator of allergy and inflammation.

Akt-I-1

B1610-1
EUR 185.00

CDK7-IN-1

B4665-1 1 mg
EUR 358.00

LPA2 antagonist 1

B4726-1 1 mg
EUR 319.00

PACAP 1-27

B5075-1 1 mg
EUR 290.00

Nociceptin (1-7)

B5087-1 1 mg
EUR 399.00

Hemokinin 1 (mouse)

B5127-1 1 mg
EUR 321.00

GIP (1-39)

B5280-1 1 mg
EUR 609.00

JMV 390-1

B5317-1 1 mg
EUR 242.00

Hemokinin 1 (human)

B5318-1 1 mg
EUR 340.00

Echistatin, ?1 isoform

B5391-.1 100 ug
EUR 583.00

SL 0101-1

B9008-1 1 mg
EUR 163.00

StemRegenin 1 (hydrochloride)

C3551-1 1 mg
EUR 118.00
Description: IC50: 127 nM in CD34+ cellsStemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist.The aryl hydrocarbon receptor (AhR ) is a protein that is encoded by the AHR gene.

IDO-IN-1

C3211-1 1 mg
EUR 139.00
Description: IC50: 59 nMIDO-IN-1 is an indoleamine-2,3-dioxygenase (IDO) inhibitor.

EZSolution? TAPI-1

2537-1
EUR 381.00

(R)-Perharidine-1

2615-1
EUR 164.00

(1-328) RAD51D (1-328 a.a.) Human Recombinant Protein

PROTO75771-1 Regular: 10ug
EUR 317.00
Description: RAD51D (1-328) Human Recombinant produced in E. coli is. a single polypeptide chain containing 351 amino acids and having a molecular mass of 37.4kDa. RAD51D (1-328) is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

XMIR-1 RNA oligo miRNA-1-3p with Xmotif

XMIR-1 10 rxn
EUR 438.00
  • Category: Exosome

AXMIR-1 RNA oligo anti-miRNA-1-3p with Xmotif

AXMIR-1 10 reactions
EUR 438.00
  • Category: Exosome

Human KRAB-associated Protein 1 (KAP-1) AssayMax ELISA Kit

EK2802-1 96 Well Plate
EUR 477.00

Human Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit

EI2200-1 96 Well Plate
EUR 477.00

Human Interleukin-1-alpha (IL-1-alpha) AssayMax ELISA Kit

EI2301-1 96 Well Plate
EUR 477.00

Human Plasminogen Activator Inhibitor-1 (PAI-1) AssayMax ELISA Kit

EP1100-1 96 Well Plate
EUR 417.00

Mouse Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit

EMI2200-1 96 Well Plate
EUR 477.00

Envelope-1, Dengue Virus Subtype 1 Recombinant Protein, Insect Cells

PROTB1PNJ5-1 Regular: 10ug
EUR 317.00
Description: Recombinant Dengue Virus Subtype 1 produced in Insect Cells is a polypeptide chain containing amino acids 281-675 and having a molecular weight of approximately 50kDa. ;Dengue Envelope-1 is purified by proprietary chromatographic technique.

TGF-b-1 Transforming Growth Factor-beta 1 Human protein

PROTP01137-1 Regular: 2.5ug
EUR 1157.00
Description: Human Transforming Growth Factor-beta 1 purified from Human Platelets having a molecular mass of 25kDa.;The TGF-b 1 is purified by proprietary chromatographic techniques.

MCP-1 Monocyte Chemotactic Protein-1 Mouse Recombinant Protein (CCL2)

PROTP10148-1 Regular: 10ug
EUR 317.00
Description: Monocyte Chemotactic Protein-1 Mouse Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 125 amino acids and having a molecular mass of 14 kDa. ;The MCP-1 is purified by proprietary chromatographic techniques.

MCP-1 Monocyte Chemotactic Protein-1 Human Recombinant Protein (CCL2)

PROTP13500-1 Regular: 20ug
EUR 317.00
Description: Monocyte Chemotactic Protein-1 Human Recombinant also known as Monocyte Chemotactic and Activating Factor (MCAF) produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 8.6kDa. ;The MCP-1 is purified by proprietary chromatographic techniques.

Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378

M04431-1 100uL
EUR 385.00
Description: Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378 tested in WB, IHC, reactive to Human

GAD1 iso1 Glutamate Decarboxylase 1 Isoform-1 Human Recombinant Protein

PROTQ99259-1 Regular: 20ug
EUR 317.00
Description: GAD1 iso1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 617 amino acids (1-594 a.a) and having a molecular mass of 69.3kDa. GAD1 iso1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

B-Raf IN 1

B4727-1 1 mg
EUR 118.00

Nociceptin (1-13)NH2

B5102-1 1 mg
EUR 184.00

JIP-1 (153-163)

B5130-1 1 mg
EUR 399.00

Nogo-66 (1-40)

B5247-1 1 mg
EUR 609.00

Orphanin FQ (1-11)

B5497-1 1 mg
EUR 226.00

R-1 Methanandamide Phosphate

C3352-1 1 mg
EUR 126.00
Description: R-1 Methanandamide Phosphate,a water soluble prodrug analog of AEA, exhibited similar activity to that of AEA in the growth inhibition of C6 glioma cells[1]. Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid (CB).

Ginkgolic Acid C15:1

C3421-1 1 mg
EUR 118.00
Description: Ginkgolic acid is an alkylphenol derivative that causes allergic skin inflammation. IC50 values of ginkgolic acid against the SUMOylation of RanGAP1-C2 are 3.0 ?M. Ginkgolic Acid, a Major Component of Ginkgo biloba Extract, inhibited SUMOylation in vitro and in vivo [1].

Individual Reaction Mix 1

G065-1 200 reactions
EUR 167.00

Anti-PARP-1 Antibody

A00122-1 100ul
EUR 397.00
Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse.

Anti-Presenilin 1 Antibody

A00138-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Presenilin 1 Antibody (PSEN1) detection. Tested with WB, IHC in Human, Mouse, Rat.

Anti-PAI-1 Antibody

A00637-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for PAI-1 Antibody (SERPINE1) detection.tested for WB in Human, Mouse, Rat.

Anti-Flk-1 Antibody

A00901-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Flk-1 Antibody (KDR) detection.tested for WB in Human, Mouse.

Anti-EDG-1 Antibody

A01502-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for EDG-1 Antibody (S1PR1) detection.tested for WB in Human, Mouse, Rat.

Anti-ROBO-1 Antibody

A01530-1 100ug
EUR 455.00
Description: Rabbit Polyclonal ROBO-1 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Bag-1 Antibody

A02423-1 50 ul
EUR 397.00
Description: Rabbit Polyclonal Bag-1 Antibody. Validated in IP, IHC and tested in Bovine, Canine, Human, Mouse, Rat.

dNTP Mix (1 ml)

9002-1
EUR 153.00

Anti-TUB 1 Antibody

A02917-1 100ug/vial
EUR 294.00

Anti-Dok-1 Antibody

A03039-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Dok-1 Antibody (DOK1) detection.tested for WB in Human, Mouse, Rat.

Anti-TFIIIB90-1 Antibody

A03761-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for TFIIIB90-1 Antibody (BRF1) detection.tested for WB in Human, Mouse.

Anti-Atrophin-1 Antibody

A03828-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Atrophin-1 Antibody (ATN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-CNG-1 Antibody

A05494-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for CNG-1 Antibody (CNGA1) detection. Tested with WB in Human, Mouse, Rat.

ANP (1-11), rat

A1009-1 1 mg
EUR 84.00
Description: Atrial Natriuretic Peptide (ANP) (C49H84N20O15S) has the sequence of H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-OH, is a 28 amino acid peptide that is synthesized, stored, and released by atrial myocytes in response to atrial distension, endothelin, and sympathetic stimulation.

alpha-1 antitrypsin fragment

A1051-1 1 mg
EUR 108.00
Description: Alpha-1 antitrypsin (A1AT) (H2N-Leu-Gln-His-Leu-Glu-Asn-Glu-Leu-Thr-His-Asp-Ile-Ile-Thr-Lys-OH), which is known as serum trypsin inhibitor, is a protease inhibitor belonging to the serpin superfamily.

BNP (1-32), human

A1105-1 1 mg
EUR 177.00
Description: Basic natriuretic peptide (BNP), now known as B-type natriuretic peptide (also BNP) or GC-B, is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).

Anti-Periphilin 1 Antibody

A06996-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Periphilin 1 Antibody (PPHLN1) detection.tested for WB in Human, Mouse.

Anti-Lyl-1 Antibody

A07491-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Lyl-1 Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-GLI-1 Antibody

A07972-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for GLI-1 Antibody (ACSS1) detection. Tested with WB in Human, Mouse, Rat.

Anti-Cerebellin 1 Antibody

A09176-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Cerebellin 1 Antibody (CBLN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-DOC-1 Antibody

A09467-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for DOC-1 Antibody (CDK2AP1) detection. Tested with WB in Human, Mouse.

Beta-Amyloid (1-11)

A1002-1 1 mg
EUR 102.00
Description: Beta-amyloid (1-11) (Abeta or A?) (C56H76N16O22) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.

Amyloid ?-Protein (1-15)

A1003-1 1 mg
EUR 113.00
Description: Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.

Anti-NPDC-1 Antibody

A12846-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for NPDC-1 Antibody (NPDC1) detection. Tested with WB in Human, Mouse, Rat.

StemRegenin 1, Free base

2642-1
EUR 131.00

IGF-1, human recombinant

P1016-.1 100 µg
EUR 763.00
Description: Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue

Supercoiled pHOT-1 DNA

TG2030-1 25 ug
EUR 246.00

Relaxed pHOT-1 DNA

TG2035-1 25 ug
EUR 246.00

Human Insulin-like Growth Factor 1 (IGF-1) AssayMax ELISA Kit

EI1001-1 96 Well Plate
EUR 477.00

Human Heat Shock Factor Protein 1 (HSF 1) AssayMax ELISA kit

EH5215-1 96 Well Plate
EUR 417.00

Mouse Insulin-like Growth Factor 1 (IGF-1) AssayMax ELISA Kit

EMI1001-1 96 Well Plate
EUR 477.00

GLP-1 Glucagon Like Peptide-1 (31 a.a.) Human Recombinant Protein

PROTP01275-1 Regular: 50ug
EUR 317.00
Description: Glucagon Like Peptide-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 31 amino acids and having a molecular mass of 3298.7 Dalton. The GLP-1 is purified by proprietary chromatographic techniques.

IL-1-alpha Interleukin-1 alpha Mouse Recombinant Protein, His Tag

PROTP01582-1 Regular: 20ug
EUR 317.00
Description: IL 1 alpha Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a) and having a molecular mass of 20.4kDa.;IL 1 alpha is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

IL-1-alpha Interleukin-1 alpha Human Recombinant Protein, His Tag

PROTP01583-1 Regular: 20ug
EUR 317.00
Description: IL-1A Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 159 amino acids fragment (113-271) with an amino-terminal hexahistidine tag and having a total molecular mass of 22.5kDa. ;The Interleukin-1 alpha His-tag is purified by proprietary chromatographic techniques.

IL-1-beta Interleukin-1 beta Mouse Recombinant Protein, His Tag

PROTP10749-1 Regular: 25ug
EUR 317.00
Description: Interleukin-1 beta Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 189 amino acids and having a molecular mass of 21 kDa. ;The IL-1b is fused to His-Tag and purified by proprietary chromatographic techniques.

IL-1-alpha Interleukin-1 alpha Rat Recombinant Protein, His Tag

PROTP16598-1 Regular: 20ug
EUR 317.00
Description: IL 1 alpha Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a) and having a molecular mass of 20.2kDa.

VAMP2 (1-94) Synaptobrevin-2 (1-94 a.a) Human Recombinant Protein

PROTP63027-1 Regular: 5ug
EUR 317.00
Description: VAMP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 118 amino acids (1-94 a.a) and having a molecular mass of 12.8kDa.;VAMP2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

IL1RL1 Human, Interleukin-1 Receptor Like-1 Human Recombinant Protein, Sf9

PROTQ01638-1 Regular: 10ug
EUR 317.00
Description: IL 1RL1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (19-328 a.a.) and fused to an 8 aa His Tag at C-terminus containing a total of 318 amino acids and having a molecular mass of 36.0kDa.;IL 1RL1 shows multiple bands between 40-57kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.

DCTN2 (1-406) Dynactin 2 (1-406 a.a.) Human Recombinant Protein

PROTQ13561-1 Regular: 20ug
EUR 317.00
Description: Dynactin 2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 429 amino acids (1-406 a.a) and having a molecular mass of 47.2kDa.;DCTN2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

STX1A (1-265) Syntaxin-1A (1-265 a.a) Human Recombinant Protein

PROTQ16623-1 Regular: 10ug
EUR 317.00
Description: STX1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (1-265 a.a) and having a molecular mass of 30.7kDa. 

Human Complete SeraMir Exosome RNA Amplification and Profiling Kit (contains cat# RA800A-1, RA805A-1, RA810A-1 components)

RA820A-1 20 profiles
EUR 1297.00
  • Category: MicroRNA Tools

Rat Complete SeraMir Exosome RNA Amplification and Profiling Kit (contains cat# RA800A-1, RA805A-1, RA812A-1 components)

RA822A-1 20 profiles
EUR 1297.00
  • Category: MicroRNA Tools

Human Complete SeraMir Exosome RNA Amplification and Profiling Kit for Media and Urine (contains cat# RA800A-1, RA805A-1, RA810A-1 and EXOTC50A-1 components)

RA820TC-1 20 profiles
EUR 1618.00
  • Category: MicroRNA Tools

Mouse Complete SeraMir Exosome RNA Amplification and Profiling Kit for Media and Urine (contains cat# RA800A-1, RA805A-1, RA810A-1 and EXOTC50A-1 components)

RA821TC-1 20 profiles
EUR 1618.00
  • Category: MicroRNA Tools

(1R,1'S,3'R/1R,1'R,3'S)-L-054,264

B7057-1 1 mg
EUR 242.00

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]

A1067-1 1 mg
EUR 108.00
Description: Sequence: LEU-GLU-ASP-GLY-PRO-LYS-PHE-LEUeukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome.

Human pre-microRNA Expression Construct Lenti-miR-181a-1 + 181b-1 MI0000270

PMIRH181a1PA-1 Bacterial Streak
EUR 684.00
  • Category: MicroRNA Tools

PSG1 Human, Pregnancy Specific Beta-1-Glycoprotein 1 Human Recombinant Protein, Sf9

PROTP11464-1 Regular: 10ug
EUR 317.00
Description: PSG1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 394 amino acids (35-419a.a.) and having a molecular mass of 44.6kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). PSG1 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

1H-1-ethyl Candesartan Cilexetil

C5023-1 1 mg
EUR 112.00
Description: 1H-1-ethyl Candesartan Cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist.

Amyloid ?-Peptide (1-42) (human)

B6057-.1 100 ug
EUR 276.00

HIV-1 Tat Protein Peptide

B1433-1 1 mg
EUR 128.00
Description: HIV-1 Tat Protein Peptide

[Nphe1]Nociceptin(1-13)NH2

B5089-1 1 mg
EUR 583.00

Galanin (1-15) (porcine, rat)

B5115-1 1 mg
EUR 519.00

187-1, N-WASP inhibitor

B5251-1 1 mg
EUR 399.00

Galanin (1-29) (rat, mouse)

B5325-1 1 mg
EUR 399.00

GLP-1 (9-36) amide

B5404-1 1 mg
EUR 561.00

Anti-TNF Receptor 1 Antibody

A00294-1 200ug
EUR 522.00
Description: Rabbit Polyclonal TNF Receptor 1 Antibody. Validated in IP, IHC, WB and tested in Human, Mouse, Rat.

Anti-Galectin 1/Lgals1 Antibody

A00470-1 100ug/vial
EUR 334.00

Anti-LOX-1/OLR1 Antibody

A00760-1 100ug/vial
EUR 294.00

Anti-Syndecan-1/SDC1 Antibody

A00991-1 100ug/vial
EUR 294.00

Anti-IRAK-1/IRAK1 Antibody

A01021-1 100ug/vial
EUR 334.00

Anti-Neurexin 1/NRXN1 Antibody

A01490-1 100ug/vial
EUR 334.00

Anti-Hexokinase 1/HK1 Antibody

A01504-1 100ug/vial
EUR 334.00

Anti-Synaptotagmin 1/SYT1 Antibody

A02314-1 100ug/vial
EUR 334.00

Anti-Syntenin-1 Monoclonal Antibody

A02475-1 100ul
EUR 397.00
Description: Mouse Monoclonal Antibody for Syntenin-1 Antibody (SDCBP) detection. Tested with WB in Human, Rat, Dog, Pig.

Anti-Dsg1/Desmoglein 1 Antibody

A02655-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Dsg1 Antibody (DSG1) detection.tested for IHC, WB in Human, Mouse, Rat.

Anti-CAF-1 p150 Antibody

A02732-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for CAF-1 p150 Antibody (CHAF1A) detection. Tested with WB in Human, Mouse.

Anti-Talin 1/TLN1 Antibody

A02859-1 100ug/vial
EUR 334.00

Anti-Islet 1/ISL1 Antibody

A02969-1 100ug/vial
EUR 334.00

Anti-Musashi 1/Msi1 Antibody

A05052-1 100ug/vial
EUR 334.00

Anti-CHST8/Galnac4St 1 Antibody

A10989-1 100ul
EUR 397.00
Description: Rabbit Polyclonal CHST8/Galnac4St 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Parathyroid Hormone (1-34), bovine

A1114-1 1 mg
EUR 166.00
Description: Parathyroid hormone (PTH) is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid, which is secreted by the chief cell of the parathyroid glands as a polypeptide containing 84 amino acids.

Parathyroid hormone (1-34) (human)

A1129-1 1 mg
EUR 166.00
Description: Parathyroid hormone (1-34) (human), (C181H291N55O51S2), a peptide with the sequence H2N-SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF-OH, MW= 4117.72.

Anti-Pyrophosphatase 1/PPA1 Antibody

A07485-1 100ug/vial
EUR 334.00

Anti-TCP-1 eta Antibody

A08169-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for TCP-1 eta Antibody (CCT7) detection. Tested with WB in Human, Mouse, Rat.

Anti-Relaxin 1/RLN1 Antibody

A08367-1 100ug/vial
EUR 334.00

Anti-TCP-1 zeta Antibody

A09373-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for TCP-1 zeta Antibody (CCT6A) detection.tested for WB in Human, Mouse, Rat.

Indo-1, AM ester: (20x50ug)

50043-1 20ST
EUR 237.00
Description: Minimum order quantity: 1 unit of 20ST

RedDot 1, 200X in water

40060-1 1mL
EUR 467.00
Description: Minimum order quantity: 1 unit of 1mL

EZSolution? StemRegenin 1, Free base

2643-1
EUR 142.00

Dr. P Kit-Solution 1

K2021010-1 50 ml
EUR 204.00
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

IL-1 beta, rat recombinant

P1019-1 1 mg
EUR 7288.00
Description: Interleukin 1 beta (IL-1?) is a proinflammatory cytokine and is produced by activated macrophages, monocytes, keratinocytes and other epithelial cells. Both IL-1? and IL-1? bind to the same receptor and have similar biological properties.

ApoA-1, human recombinant protein

P1052-.1 100 µg
EUR 313.00
Description: Apolipoprotein A-1 (ApoA-1) is a glycoprotein produced in the liver and intestine that is the major protein component of high density lipoprotein (HDL) particles. ApoA-1 is involved in the reverse transport of cholesterol from peripheral tissues to the liver for recycling and excretion.

ApoA-1, human recombinant protein

P1052-1 1 mg
EUR 1553.00
Description: Apolipoprotein A-1 (ApoA-1) is a glycoprotein produced in the liver and intestine that is the major protein component of high density lipoprotein (HDL) particles. ApoA-1 is involved in the reverse transport of cholesterol from peripheral tissues to the liver for recycling and excretion.

WNT-1, human recombinant protein

P1068-1 1 mg
EUR 6940.00
Description: The WNT gene family compose of structurally related genes that encode secreted signaling proteins. These proteins have been involved in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

Anti-Galectin 1/LGALS1 Antibody

PB9240-1 100ug/vial
EUR 334.00

Recombinant Human Gremlin-1 Protein

PROTO60565-1 50ug
EUR 317.00
Description: Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle.  Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7.  It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 18.3  kDa protein containing 160 amino acid residues.

ORM1 Orosomucoid 1 Human protein

PROTP02763-1 Regular: 10ug
EUR 317.00
Description: The Human Orosomucoid 1 produced from Human pooled serum has a molecular mass of 21.56kDa (calculated without glycosylation) containing 183 amino acid residues.

Recombinant Human Galectin-1 Protein

PROTP09382-1 50ug
EUR 317.00
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.

Recombinant Human PECAM-1 Protein

PROTP16284-1 50ug
EUR 317.00
Description: PECAM is transmembrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. It is highly expressed at endothelial cell junctions, and also expressed in platelets and in most leukocyte sub-types. The primary function of PECAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. PECAM-1 has been implicated in the pathogenesis of various inflammation related disorders, including thrombosis, multiple sclerosis (MS), and rheumatoid arthritis. The human PECAM-1 gene codes for a 738 amino acid transmembrane glycoprotein containing a 118 amino acid cytoplasmic domain, a 19 amino acid transmembrane domain, and a 574 amino acid extracellular domain. Recombinant human PECAM-1 is a 572 amino acid glycoprotein comprising the extracellular domain of PECAM-1. Monomeric glycosylated PECAM-1 migrates at an apparent molecular weight of approximately 80.0-95.0 kDa by SDS-PAGE analysis under reducing conditions

Anti-Presenilin 1 Monoclonal Antibody

M00138-1 100ug
EUR 397.00
Description: Rabbit Monoclonal Presenilin 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Galectin 1 Monoclonal Antibody

M00470-1 100ug
EUR 397.00
Description: Rabbit Monoclonal Galectin 1 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Anti-DJ-1 Monoclonal Antibody

M00757-1 100ul
EUR 397.00
Description: Mouse Monoclonal DJ-1 Antibody. Validated in IHC, WB and tested in Bovine, Human.

Anti-Enolase 1 Monoclonal Antibody

M01250-1 100ul
EUR 397.00
Description: Anti-Enolase 1 Monoclonal Antibody tested in WB, IF, ICC, IHC, reactive to Human, rat, mouse, cow, pig, horse

Our immunohistochemical investigations have also highlighted the presence of actin-containing microstructures called myobridges that connect the retinal VSMCs to one another. Although further work is still needed, studies to date investigating myogenic mechanisms in the retina have contributed to a better understanding of how blood flow is regulated in this tissue. They also provide a basis to direct future research into retinal diseases where blood flow changes contribute to the pathology.