Host-microbiome interactions: the aryl hydrocarbon receptor as a critical node in tryptophan metabolites to brain signaling.

Tryptophan (Trp) is not only a nutrient enhancer but also has systemic effects. Trp metabolites signaling through the well-known aryl hydrocarbon receptor (AhR) constitute the interface of microbiome-gut-brain axis.

However, the pathway through which Trp metabolites affect central nervous system (CNS) function have not been fully elucidated. AhR participates in a broad variety of physiological and pathological processes that also highly relevant to intestinal homeostasis and CNS diseases.

4-Arm PEG-GA
abx085098-200l	Abbexa	200 µl	EUR 712.5

4-Arm PEG-GA
abx085098-20kDa5g	Abbexa	20 kDa; 5 g	EUR 760.8

4-Arm PEG-GA
abx085098-2kDa1g	Abbexa	2 kDa; 1 g	EUR 427.2

8-Arm PEG-GA
abx085109-100l	Abbexa	100 µl	EUR 250

8-Arm PEG-GA
abx085109-10kDa1g	Abbexa	10 kDa; 1 g	EUR 393.6

8-Arm PEG-GA
abx085109-10kDa5g	Abbexa	10 kDa; 5 g	EUR 744

8-Arm PEG-GA
abx085109-1ml	Abbexa	1 ml	EUR 275

8-Arm PEG-GA
abx085109-200l	Abbexa	200 µl	EUR 250

8-Arm PEG-GA
abx085109-20kDa5g	Abbexa	20 kDa; 5 g	EUR 744

8-Arm PEG-GA
abx085109-40kDa1g	Abbexa	40 kDa; 1 g	EUR 427.2

PEG-G-CSF
RP250004	Biochempeg	Inquire	Ask for price

4-Arm PEG-GAS
abx085093-100l	Abbexa	100 µl	EUR 312.5

4-Arm PEG-GAS
abx085093-10kDa1g	Abbexa	10 kDa; 1 g	EUR 526.8

4-Arm PEG-GAS
abx085093-10kDa5g	Abbexa	10 kDa; 5 g	EUR 878.4

4-Arm PEG-GAS
abx085093-1ml	Abbexa	1 ml	EUR 350

4-Arm PEG-GAS
abx085093-200l	Abbexa	200 µl	EUR 312.5

4-Arm PEG-GAS
abx085093-20kDa5g	Abbexa	20 kDa; 5 g	EUR 878.4

4-Arm PEG-GAS
abx085093-2kDa1g	Abbexa	2 kDa; 1 g	EUR 477.6

4-Arm PEG-GAA
abx085100-100l	Abbexa	100 µl	EUR 275

4-Arm PEG-GAA
abx085100-10kDa1g	Abbexa	10 kDa; 1 g	EUR 460.8

4-Arm PEG-GAA
abx085100-10kDa5g	Abbexa	10 kDa; 5 g	EUR 760.8

4-Arm PEG-GAA
abx085100-1ml	Abbexa	1 ml	EUR 300

4-Arm PEG-GAA
abx085100-200l	Abbexa	200 µl	EUR 275

4-Arm PEG-GAA
abx085100-20kDa5g	Abbexa	20 kDa; 5 g	EUR 760.8

4-Arm PEG-GAA
abx085100-2kDa1g	Abbexa	2 kDa; 1 g	EUR 427.2

8-Arm PEG-GAA
abx085111-100l	Abbexa	100 µl	EUR 250

8-Arm PEG-GAA
abx085111-10kDa1g	Abbexa	10 kDa; 1 g	EUR 393.6

8-Arm PEG-GAA
abx085111-10kDa5g	Abbexa	10 kDa; 5 g	EUR 744

8-Arm PEG-GAA
abx085111-1ml	Abbexa	1 ml	EUR 275

8-Arm PEG-GAA
abx085111-200l	Abbexa	200 µl	EUR 250

8-Arm PEG-GAA
abx085111-20kDa5g	Abbexa	20 kDa; 5 g	EUR 744

8-Arm PEG-GAA
abx085111-40kDa1g	Abbexa	40 kDa; 1 g	EUR 427.2

8-Arm PEG-GAS
abx085116-100l	Abbexa	100 µl	EUR 275

8-Arm PEG-GAS
abx085116-10kDa1g	Abbexa	10 kDa; 1 g	EUR 393.6

8-Arm PEG-GAS
abx085116-10kDa5g	Abbexa	10 kDa; 5 g	EUR 744

8-Arm PEG-GAS
abx085116-1ml	Abbexa	1 ml	Ask for price

8-Arm PEG-GAS
abx085116-200l	Abbexa	200 µl	EUR 837.5

8-Arm PEG-GAS
abx085116-20kDa5g	Abbexa	20 kDa; 5 g	EUR 744

8-Arm PEG-GAS
abx085116-40kDa1g	Abbexa	40 kDa; 1 g	EUR 427.2

rHu PEG-GCSF (cGMP)
AK9032-0000	Akron Biotech	1mg	Ask for price

PCL(5K)-PEG-Galactose
abx085406-100l	Abbexa	100 µl	EUR 762.5

PCL(5K)-PEG-Galactose
abx085406-1ml	Abbexa	1 ml	Ask for price

PCL(5K)-PEG-Galactose
abx085406-200l	Abbexa	200 µl	Ask for price

PCL(5K)-PEG-Galactose
abx085406-2kDa1g	Abbexa	2 kDa; 1 g	EUR 684

PCL(5K)-PEG-Galactose, 2K
HE116072-2K-G	Biochempeg	G	EUR 430.8
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

KRIBIOLISA PEG-GCSF (Pegylated Filgrastim) ELISA
KBBA10	Krishgen	1 x 96 wells	EUR 676.5

18:1 PEG1000 PE
HY-155932	MedChemExpress	Get quote	Ask for price
Description: 18:1 PEG1000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

18:1 PEG3000 PE
HY-155933	MedChemExpress	Get quote	Ask for price
Description: 18:1 PEG3000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

18:1 PEG5000 PE
HY-155934	MedChemExpress	Get quote	Ask for price
Description: 18:1 PEG5000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

18:1 PEG2000 PE
HY-144010	MedChemExpress	Get quote	Ask for price
Description: 18:1 PEG2000 PE (18:1 PEG-PE) is a polyethyleneglycol/phosphatidyl-ethanolamine conjugate. 18:1 PEG2000 PE can be used for drug delivery[1].

18:1 PEG350 PE
HY-155930	MedChemExpress	Get quote	Ask for price
Description: 18:1 PEG350 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

18:1 PEG550 PE
HY-155931	MedChemExpress	Get quote	Ask for price
Description: 18:1 PEG550 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

AzoDye-1 PEG10 Alkyne
2415-1mg	AAT Bioquest	1 mg	EUR 151
Description: AzoDye-1 PEG10 alkyne is an excellent building block for labeling azide-containing molecules.

PEG3-tetrazine, 1 g
1978-1g	Lumiprobe	1 g	EUR 793.2

DBCO PEG13 NHS 1 µmol scale
26-6746-01	Gene Link	1 Each	Ask for price

AzoDye-1 PEG10 Succinimidyl Ester
2403-5mg	AAT Bioquest	5 mg	EUR 97
Description: AzoDye-1 PEG10 Succinimidyl Ester is an excellent building block for labeling amino-containing molecules.

pEGFP-1
PVTY00993	Nova Lifetech	2ug	EUR 280

JBScreen Membrane 1 (PEG 400 to PEG 2000 MME based)
M-CS-301L	MiTeGen	24 solutions	EUR 414
Description: JBScreen Membrane 1 (PEG 400 to PEG 2000 MME based)

PEG3 dicarboxylic acid, 1 g
1715-1g	Lumiprobe	1 g	EUR 423.6

pEGFP- MD2- 1
PVT10180	Lifescience Market	2 ug	EUR 361.2

DBCO PEG4 NHS 1 µmol scale
26-6745-01	Gene Link	1 Each	Ask for price

Azide PEG4 NHS 1 µmol scale
26-6754-01	Gene Link	1 Each	Ask for price

Lenti ORF clone of Peg10 (mGFP-tagged) - Mouse paternally expressed 10 (Peg10), transcript variant 1, encoding isoform 1
MR224445L4	Origene Technologies GmbH	10 µg	Ask for price

Alkyne PEG4 NHS 1 µmol scale
26-6752-01	Gene Link	1 Each	Ask for price

JBScreen Classic 1 (PEG 400 to 3000 based)
M-CS-101L	MiTeGen	24 solutions	EUR 249
Description: JBScreen Classic 1 (PEG 400 to 3000 based)

Peg12 sgRNA CRISPR Lentivector (Rat) (Target 1)
K6370802	ABM	1.0 ug DNA	EUR 184.8

PEG30K-Cys-AEEAc-Fibrinopeptide A (1-15)
4066201.05	Bachem	0.5 mg	EUR 240.45

PEG30K-Cys-AEEAc-Fibrinopeptide A (1-15)
4066201.1	Bachem	1 mg	EUR 422.42

PEG30K-Cys-AEEAc-Fibrinopeptide A (1-15)
H-8348.0500	Bachem	0.5mg	EUR 410.4
Description: Sum Formula: C66H101N17O29S+PEG30K

PEG30K-Cys-AEEAc-Fibrinopeptide A (1-15)
H-8348.1000	Bachem	1.0mg	EUR 691.2
Description: Sum Formula: C66H101N17O29S+PEG30K

PEG10 sgRNA CRISPR Lentivector (Human) (Target 1)
K1626702	ABM	1.0 ug DNA	EUR 184.8

Peg12 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K3769502	ABM	1.0 ug DNA	EUR 184.8

Peg10 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4676402	ABM	1.0 ug DNA	EUR 184.8

pEGFP- 1 Plasmid
PVT1201	Lifescience Market	2 ug	EUR 319.2

PEG10 (untagged)-Human paternally expressed 10 (PEG10), transcript variant 1
SC108513	Origene Technologies GmbH	10 µg	Ask for price

PEG10 (untagged)-Human paternally expressed 10 (PEG10) transcript variant 1
SC328573	Origene Technologies GmbH	10 µg	Ask for price

PEG10 (untagged)-Human paternally expressed 10 (PEG10), transcript variant 1
SC318188	Origene Technologies GmbH	10 µg	Ask for price

PEG10 (untagged)-Human paternally expressed 10 (PEG10), transcript variant 1
SC324334	Origene Technologies GmbH	10 µg	Ask for price

Lenti ORF clone of Peg10 (Myc-DDK-tagged) - Mouse paternally expressed 10 (Peg10), transcript variant 1, encoding isoform 1
MR224445L3	Origene Technologies GmbH	10 µg	Ask for price

Biotin PEG2 amine *CAS 138529-46-1*
3014-5mg	AAT Bioquest	5 mg	EUR 109
Description: This carbonyl-reactive biotin derivative contains a long arm (~20 angstrom) increase its avidin-binding affinity.

Azide PEG3 Maleimide 1 µmol scale
26-6761-01	Gene Link	1 Each	Ask for price

Peg10 (untagged) - Mouse paternally expressed 10 (Peg10), transcript variant 1, (10ug)
MC223182	Origene Technologies GmbH	10 µg	Ask for price

PEG10 (GFP-tagged) - Human paternally expressed 10 (PEG10), transcript variant 1
RG208683	Origene Technologies GmbH	10 µg	Ask for price

PEG10 (GFP-tagged) - Human paternally expressed 10 (PEG10), transcript variant 1
RG229935	Origene Technologies GmbH	10 µg	Ask for price

PEG10 (GFP-tagged) - Human paternally expressed 10 (PEG10), transcript variant 1
RG231501	Origene Technologies GmbH	10 µg	Ask for price

PEG10 (GFP-tagged) - Human paternally expressed 10 (PEG10), transcript variant 1
RG223371	Origene Technologies GmbH	10 µg	Ask for price

Lenti ORF particles, Peg10 (GFP-tagged) - Mouse paternally expressed 10 (Peg10), transcript variant 1, encoding isoform 1, 200ul, >10^7 TU/mL
MR224445L4V	Origene Technologies GmbH	200 µl	Ask for price

Peg10 (GFP-tagged) - Mouse paternally expressed 10 (Peg10) transcript variant 1, (10ug)
MG224445	Origene Technologies GmbH	10 µg	Ask for price

Peg10 (GFP-tagged) - Mouse paternally expressed 10 (Peg10) transcript variant 1, (10ug)
MG225144	Origene Technologies GmbH	10 µg	Ask for price

Peg10 (Myc-DDK-tagged) - Mouse paternally expressed 10 (Peg10), transcript variant 1
MR224445	Origene Technologies GmbH	10 µg	Ask for price

Peg10 (Myc-DDK-tagged) - Mouse paternally expressed 10 (Peg10), transcript variant 1
MR225144	Origene Technologies GmbH	10 µg	Ask for price

PEG10 (Myc-DDK-tagged)-Human paternally expressed 10 (PEG10), transcript variant 1
RC231501	Origene Technologies GmbH	10 µg	Ask for price

PEG10 (Myc-DDK-tagged)-Human paternally expressed 10 (PEG10), transcript variant 1
RC229935	Origene Technologies GmbH	10 µg	Ask for price

PEG10 (Myc-DDK-tagged)-Human paternally expressed 10 (PEG10), transcript variant 1
RC223371	Origene Technologies GmbH	10 µg	Ask for price

PEG10 (Myc-DDK-tagged)-Human paternally expressed 10 (PEG10), transcript variant 1
RC208683	Origene Technologies GmbH	10 µg	Ask for price

JBScreen PEG/Salt 1
CS-141	Jena Bioscience GmbH	24solutions	EUR 198.63

JBScreen PEG/Salt 1
M-CS-141	MiTeGen	24 solutions	EUR 263
Description: JBScreen PEG/Salt 1

pEGFP-C1-LMP-1
PPL80108-2a	Bioworld Biotech	1149bp	EUR 218
Description: pEGFP-C1

pEGFP-C3-Bif-1
PPL00333-2a	Bioworld Biotech	1098bp	EUR 218
Description: pEGFP-C3

Lenti ORF particles, Peg10 (Myc-DDK-tagged) - Mouse paternally expressed 10 (Peg10), transcript variant 1, encoding isoform 1, 200ul, >10^7 TU/mL
MR224445L3V	Origene Technologies GmbH	200 µl	Ask for price

PEG3 (untagged)-Human paternally expressed 3 (PEG3), transcript variant 1
SC128281	Origene Technologies GmbH	10 µg	Ask for price

PEG3 sgRNA CRISPR Lentivector (Human) (Target 1)
K1626502	ABM	1.0 ug DNA	EUR 184.8

Peg3 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4341802	ABM	1.0 ug DNA	EUR 184.8

pEGFP-N1-Caspase 1
PPL00392-2e	Bioworld Biotech	1212bp	EUR 218
Description: pEGFP-N1

Halo Chloro Tag C6 PEG4 NHS 1 µmol scale
26-6455-01	Gene Link	1 Each	Ask for price

PEG3AS sgRNA CRISPR Lentivector (Human) (Target 1)
K1626602	ABM	1.0 ug DNA	EUR 184.8

PEG3 (GFP-tagged) - Human paternally expressed 3 (PEG3), transcript variant 1
RG215328	Origene Technologies GmbH	10 µg	Ask for price

iFluor®488-PEG12-dUTP *1 mM in Tris Buffer (pH 7.5)*
17041	AAT Bioquest	25 nmoles	EUR 101
Description: The dye-modified deoxyuridine 5'-triphosphates are one of the most common methods to produce dye-labelled DNA via the conventional enzymatic incorporation methods such as reverse transcription, nick translation, random primed labeling, or PCR.

iFluor®488-PEG12-dUTP *1 mM in Tris Buffer (pH 7.5)*
17041-25nmoles	AAT Bioquest	25 nmoles	EUR 99
Description: The dye-modified deoxyuridine 5'-triphosphates are one of the most common methods to produce dye-labelled DNA via the conventional enzymatic incorporation methods such as reverse transcription, nick translation, random primed labeling, or PCR.

iFluor®555-PEG12-dUTP *1 mM in Tris Buffer (pH 7.5)*
17042	AAT Bioquest	25 nmoles	EUR 101
Description: The dye-modified deoxyuridine 5'-triphosphates are one of the most common methods to produce dye-labelled DNA via the conventional enzymatic incorporation methods such as reverse transcription, nick translation, random primed labeling, or PCR.

iFluor®555-PEG12-dUTP *1 mM in Tris Buffer (pH 7.5)*
17042-25nmoles	AAT Bioquest	25 nmoles	EUR 99
Description: The dye-modified deoxyuridine 5'-triphosphates are one of the most common methods to produce dye-labelled DNA via the conventional enzymatic incorporation methods such as reverse transcription, nick translation, random primed labeling, or PCR.

iFluor®647-PEG12-dUTP *1 mM in Tris Buffer (pH 7.5)*
17043	AAT Bioquest	25 nmoles	EUR 101
Description: The dye-modified deoxyuridine 5'-triphosphates are one of the most common methods to produce dye-labeled DNA via conventional enzymatic incorporation methods such as reverse transcription, nick translation, random primed labeling, or PCR.

iFluor®647-PEG12-dUTP *1 mM in Tris Buffer (pH 7.5)*
17043-25nmoles	AAT Bioquest	25 nmoles	EUR 99
Description: The dye-modified deoxyuridine 5'-triphosphates are one of the most common methods to produce dye-labelled DNA via the conventional enzymatic incorporation methods such as reverse transcription, nick translation, random primed labeling, or PCR.

JBScreen PEG/Salt 1 - 4
CS-145	Jena Bioscience GmbH	4Kits	EUR 670.49

JBScreen PEG/Salt 1 - 4
M-CS-145	MiTeGen	4 Kits	EUR 858
Description: JBScreen PEG/Salt 1 - 4

pEGFP-Gsdmd-m(1-976)
PVT22039	Nova Lifetech	2ug	EUR 280

pEGFP-C1-TYR-c-1
PVT20226	Nova Lifetech	2ug	EUR 280

pEGFP-N1-PTEN(1-185aa)
PPL00065-2d	Bioworld Biotech	555bp	EUR 218
Description: pEGFP-N1

PEG3 (Myc-DDK-tagged)-Human paternally expressed 3 (PEG3), transcript variant 1
RC215328	Origene Technologies GmbH	10 µg	Ask for price

Lenti-ORF clone of PEG10 (mGFP-tagged)-Human paternally expressed 10 (PEG10), transcript variant 1
RC231501L4	Origene Technologies GmbH	10 µg	Ask for price

Via the AhR-dependent mechanism, Trp metabolites connect bidirectional signaling between the gut microbiome and the brain, mediated via immune, metabolic, and neural (vagal) signaling mechanisms, with downstream effects on behavior and CNS function. These findings shed light on the complex Trp regulation of microbiome-gut-brain axis and add another facet to our understanding that dietary Trp is expected to be a promising noninvasive approach for alleviating systemic diseases.